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Adulteress
Negative Connotation
The word 'adulteress' has a negative and judgmental tone, implying moral disapproval. 
Gender Specific
'Adulteress' is specific to women; the male equivalent is 'adulterer'. 
Historical Usage
'Adulteress' is less common today and can sound archaic; modern language often uses 'cheating' or 'unfaithful' instead. 