Antagonize/ænˈtæɡənaɪz/ Definition 1 of 2Pro Tip 1/3Negative Connotation Antagonize implies causing someone to become hostile. Don't antagonize your colleagues with harsh words. Pro Tip 2/3May Escalate Using 'antagonize' suggests actions may lead to greater conflict. His teasing might antagonize her into arguing. Pro Tip 3/3Not Accidental Antagonizing often implies intent, not an accidental effect. She didn't mean to antagonize him with her comments.