Calamine/ˈkæləmaɪn/ Definition 1 of 3Pro Tip 1/2Skin Relief Use 'calamine' to refer to the soothing lotion for insect bites, sunburn, or rashes. I always pack calamine when going camping. Pro Tip 2/2Not a Drink 'Calamine' may sound like a beverage, but it's only for external use. Remember, calamine lotion is not to be ingested!