Cretinous has a strong negative connotation; use it to express disapproval.

Negatively Charged

Used in informal settings, 'cretinous' can sound disrespectful in formal situations.

Colloquial Usage

It expresses a strong emotion of frustration or annoyance.

Emotionally Strong

Specifically refers to a condition related to thyroid deficiency; it's technical, not an insult.

Medical Term

Use it with sensitivity, as it pertains to a serious health issue.

Serious Condition

In a medical context, it's descriptive, not negative.

Not Derogatory

 easily butter butter flour don't use margarine please whatever you do butter flour a little bit of baking powder tiny a little bit of sugar a pinch of salt in the oven and you'll have a lovely Fluffy's gone whatever you do don't yell by one because some cretinous company will have put all sorts of preservatives