Depot/ˈdiːpəʊ/ Definition 1 of 4Pro Tip 1/2Transport Hub A depot can be a central point in a transport network, where passengers and goods transition. After arriving at the train depot, we switched to a bus. Pro Tip 2/2Geographic Specificity Depots are often located on the outskirts or in industrial areas for convenience and space. The new depot's location allows for easy highway access.