Detox/ˈdiːtɑːks/ Definition 1 of 3Pro Tip 1/3Medical Recovery Refers to the medical process of stopping substance abuse. He was in detox for a month. Pro Tip 2/3Facility Specific Often associated with professional facilities like clinics. She checked into a detox clinic. Pro Tip 3/3Physical Health Implies physical treatment to remove toxins. The detox helped clear his system.