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Dyspeptic
Not Always Literal
When used metaphorically, 'dyspeptic' describes someone's sour mood and not actual indigestion. 
Emotional Response
'Dyspeptic' can imply that someone's grumpiness is a temporary reaction, possibly from discomfort. 
Medical Context
In medical contexts, it refers specifically to gastrointestinal distress, but laypersons often use it loosely. 