
Enervate
Physical Impact
Use 'enervate' when describing physical exhaustion or weakening, not just a lack of enthusiasm or boredom. 
Metaphorical Use
'Enervate' can be used metaphorically for things that cannot literally be tired, like an economy or a policy. 
Negative Connotation
'Enervate' carries a negative connotation, implying a reduction of effectiveness or strength. 