Ghetto/ˈɡetəʊ/ Definition 1 of 4Pro Tip 1/2Negative Connotation Often implies poverty, crime, and segregation, used carefully to avoid offense. She volunteered to help improve living conditions in the ghetto. Pro Tip 2/2Not Interchangeable Not a synonym for 'poor'; refers specifically to a dense, urban area. The rent in the ghetto was still high despite the poor living conditions.