Use it when someone or something is slightly irritating or when you need a break from an activity.

Annoyance Cease

Appropriate for casual conversations among friends, not for professional or formal settings.

Informal Tone

Implies that you need emotional relief from a conversation or activity that's been taxing.

Suggests that you've made your point repeatedly and it's time to stop, as it's not being effective.

Indicates a desire to move the conversation away from a particular subject that's becoming bothersome.

Use the phrase to politely signal that someone's point, though valid, is becoming a source of irritation.