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Go up in smoke

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Metaphorical UsagePlay
Often used metaphorically to describe wasted efforts or failed ambitions, not just actual plans. SlideAfter failing the audition, her dreams of becoming an actress went up in smoke.
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Negative OutcomePlay
The phrase implies a sense of disappointment or a negative outcome to a hopeful situation. SlideTheir championship hopes went up in smoke after the star player got injured.
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Irreversible ConsequencePlay
Used to express that something has been irreversibly damaged or lost. SlideThe secret recipe went up in smoke when the chef passed away without writing it down.