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Have shot your bolt
Metaphorical Origin
The phrase comes from crossbow archery, where a 'bolt' is a type of arrow, symbolizing used-up effort. 
Common Misuse
Don't confuse it with 'shooting oneself in the foot', which means causing self-harm by mistake. 
Use in Failure
It's often used when someone has failed after giving their all, not just when they're tired. 