Use when someone's breathing hard from activities like running or climbing.

Physical Exertion

The phrase can also convey frustration or fatigue feelings from the effort.

Emotional Intensity

Often shows someone is visibly upset or impatient about something.

Signals that a person is not just mildly irritated but significantly bothered.

Used when efforts result in failure, specifically after trying very hard.

Highlights the ineffectiveness despite someone's dedicated effort or hard work.