Interference/ˌɪntərˈfɪrəns/ Definition 1 of 5Pro Tip 1/2Physical or Abstract Interference can describe physical blockages or abstract disruptions in plans. The crowd's interference with the parade route caused a delay. Pro Tip 2/2Negative Connotation 'Interference' often implies a negative outcome or an unwanted interruption. His constant interference made it hard to finish our project on time.