Irremediable
/ˌɪrɪˈmiːdiəbl/
Definition 1 of 1
Pro Tip 1/3Permanent State
Use 'irremediable' to express a permanent, unchangeable condition, often because it’s too late to fix. 
The neglect had led to irremediable consequences for the ecosystem.
Pro Tip 2/3Severity Impact
It emphasizes the severity of a situation, marking it as beyond help or cure. 
His decision was made with irremediable seriousness, no turning back.
Pro Tip 3/3Negative Outcome
Associated with negative outcomes, it's rarely used in a positive or neutral context. 
The company's reputation suffered irremediable damage after the scandal.