Isolation/ˌaɪsəˈleɪʃn/ Definition 1 of 4Pro Tip 1/2Emotional Weight Isolation carries a negative feeling; loneliness that is often unwanted or sad. After moving out, he felt a strong sense of isolation. Pro Tip 2/2Not by Choice Isolation in this sense is usually not by personal choice, but due to external factors. The pandemic led to the isolation of many people.