Niggle/ˈnɪɡl/ Definition 1 of 3Pro Tip 1/2Slight Annoyance Use 'niggle' when irritation is minor and continuous, not for major problems. The constant clicking of her pen began to niggle at him. Pro Tip 2/2Emotional Impact 'Niggle' suggests a psychological effect, often leading to distraction or frustration. A nagging doubt niggled at her confidence before the speech.