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Not the sharpest knife in the drawer
Metaphorical Usage
The phrase is a metaphor that implies a lack of mental sharpness, comparing a person's intellect to a dull knife. 
Avoid Insults
It can be offensive or humorous depending on tone and relationship. Use with caution to avoid hurting feelings. 
Informal Context
Suitable for casual conversations, but it's not appropriate in formal or professional settings. 