Prickle/ˈprɪkl/ Definition 1 of 3Pro Tip 1/2Physical Objects Used to describe small, sharp items often found on plants like roses or cacti. Watch out for the prickles when you pick up the rose. Pro Tip 2/2Touch Sensitivity Used when something physically touches your skin lightly, causing discomfort or pain. She brushed against the bush and tiny prickles jabbed her arm.