Resignation/ˌrezɪɡˈneɪʃn/ Definition 1 of 4Pro Tip 1/2Voluntary Exit Resignation implies you chose to leave, not fired or laid off. After considering his options, he submitted his resignation. Pro Tip 2/2Professional Tone Use a formal tone when resigning to maintain professionalism. She wrote a cordial letter expressing her regret as she offered her resignation.