Set up shop
Definition 1 of 2
Pro Tip 1/3Business Centric
The phrase usually involves a physical location where transactions occur. 
They're looking to set up shop where there's a lot of foot traffic.
Pro Tip 2/3Figurative Use
Can mean preparing to work seriously, not always a commercial activity. 
Although a baker, he'd often set up shop in the park with his easel.
Pro Tip 3/3Starting Fresh
Suggests a new beginning or entering a new market. 
After years abroad, she'll set up shop back in her home country.