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Spittle
Negative Connotation
Spittle often implies disgust or disrespect when linked to spitting at someone or something. 
Unintentional Action
'Spittle' can refer to saliva expelled accidentally while talking or laughing. 
Informal Usage
The term 'spittle' is less formal and can sound crude; 'saliva' is typically preferable in formal contexts. 